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The Church or Sanctuary of the Madonna di San Biagio is situated at the foot of the hill of Montepulciano, in the bottom of a driveway lined with cypress trees, it was built by Antonio da Sangallo the Elder between 1518 and 1545 and is a masterpiece of the sixteenth century Tuscany art. The origin of the church is tied to a miraculous event took place on 23 April 1518, when two women and a shepherd, passing in front of a fresco depicting the Madonna and Child in her lap and St. Francis,  saw that the Virgin's eyes moved as if she was alive.

The church in travertine, has a Greek cross plan with central dome and a semicircular apse and two bell towers. The Baroque interior is frescoed, has a fine high altar with reredos of 1584 with four marble statues of saints, work of Ottaviano Lazzerini, above the altar is a stained glass window with Madonna and Saints by Michelangelo da Cortona. 

Church or Sanctuary of the Madonna di San Biagio, Montepulciano, Siena	Church or Sanctuary of the Madonna di San Biagio, Montepulciano, Siena